The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an\nexcipient. Designated as ACV-oxalic acid, methods for the preparation thereof and its use in pharmaceutical\napplications are described. The co-amorphous ACV-oxalic acid was characterized by powder X-ray diffraction,\ndifferential scanning calorimetry and thermogravi metric analysis. Stability with respect to relative humidity (RH) for\nthe co-amorphous ACV-oxalic acid was evaluated and compared with the parent ACV. The aqueous solubility of the\nco-amorphous ACV-oxalic acid was significantly improved (about 8 times more soluble) at 35�°C compared to that of\nthe parent Acyclovir base.
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